Janus Kinase InhibitorsJanus kinase inhibitors have traditionally been used to treat:
- Rheumatoid arthritis
- Psoriatic arthritis
- Ulcerative colitis
- Each of the approved inhibitors targets specific enzymes
Current Ankylosing Spondylitis TreatmentsJanus kinase inhibitors are not given to individuals right away. However, it could be an option if first and second-line treatments are not working. Treatments usually consist of:
NSAIDsNonsteroidal anti-inflammatory medications are the most commonly used to treat ankylosing inflammation, pain, and stiffness.
ChiropracticChiropractic physical therapy is a major part of ankylosing spondylitis treatment keeping the spine flexible and as healthy as possible. A chiropractic/physical therapy team design and develop specific exercises to fit individual needs, which include:
- Stretching and Range-of-motion exercises help maintain flexibility in the joints
- Sleeping and walking posture adjustment exercises
- Abdominal and spinal exercises to maintain a healthy posture
- Strength training
Second-Line TherapiesIf nonsteroidal anti-inflammatory medications do not relieve symptoms, then biological medications could be prescribed. This class of medications includes:
Tumor Necrosis FactorTumor necrosis factor blockers work by targeting cell protein that is part of the immune system, known as tumor necrosis alpha. This protein causes inflammation in the body, and the blockers suppress it.
Interleukin 17 InhibitorsInterleukin 17 in the body’s immune system defends against infection. It uses an inflammatory response to fight infections. The IL-17 inhibitors suppress the inflammatory response and help reduce symptoms.
Other Treatment Options
Lifestyle AdjustmentsFollowing a medical treatment plan is often combined with diet and lifestyle adjustments that are recommended to help with the condition, these include:
- Being as physically active as possible will help:
- Improve/maintain a healthy posture
- Maintain flexibility
- Ease pain
- Applying heat and ice will help alleviate:
- Practicing posture exercises
SurgeryMost individuals with ankylosing spondylitis do not require surgery. However, a doctor could recommend surgery if there is joint damage, the hip-joint needs to be replaced, or if the pain is severe.
Inhibitor PotentialStudies are ongoing in the treatment of ankylosing spondylitis. The drug is currently in Phase 3 trials for the treatment of adults. The trial results have shown patients with active ankylosing spondylitis showed improvement in:
- Back pain