The Link Between Neuroinflammation & Neurodegenerative Diseases

Introduction

The brain sends neuron signals to the body to function for everyday movements like walking, running, or resting. These signals travel from the spinal cord through the numerous nerve roots connected to the muscles, tissue, and ligaments that support the joints and organs from multiple factors. However, these factors do affect the body over time, triggering issues that cause pain and discomfort to the body. When this happens, it disrupts the signals from traveling to and forth in the brain, causing dysfunction in the body and leading to neurological disorders associated with neuroinflammation. Today’s article looks at neuroinflammation, how it affects the body, and what is the link between neuroinflammation and neurodegenerative diseases. We refer patients to certified providers specializing in neurological treatments to help many individuals dealing with neuroinflammation associated with neurodegenerative diseases. We also guide our patients by referring to our associated medical providers based on their examination when it’s appropriate. We find that education is the solution to asking our providers insightful questions. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

What Is Neuroinflammation?

Are you experiencing fatigue and losing focus from your brain? Do you constantly feel stressed or overworked? Or how about developing the risk of Alzheimer’s or other neurological diseases? Many of these symptoms are correlated with neuroinflammation in the brain. Neuroinflammation is defined as an inflammatory response that affects either the brain or the spinal cord. The body has an extensive network known as the immune system, which produces cytokines, antibodies, white blood cells, and other chemicals that protect the body from foreign invaders. Producing cytokines triggers inflammation in the body where the alien invaders are eliminated. The brain surprisingly has its immune system, which provides maintenance and plasticity. When traumatic factors begin to affect the brain’s immune system, the nociceptors become hypersensitive and overexcited due to the results of tissue injuries and inflammation in the peripheral nervous system. Studies reveal that inflammation in the peripheral nervous system results from hyperactivity in the nervous system, which implicates either a positive or negative outcome for the brain.

How Does Neuroinflammation Affect The Body?

Since neuroinflammation has positive or negative outcomes in the nervous system, it can also trigger the body, making it dysfunctional. Studies reveal that neuroinflammation is mediated by the production of cytokines, ROS (reactive oxygen species), and secondary messengers that becomes the consequences of neuroinflammatory responses. This means that the inflammatory effects are taken into account depending on the intensity and duration of the immune signals in the nervous system, which can be either negative or positive. The positive aspects of neuroinflammation include:

• Reorganization of host priorities (immune-brain communication)
• Tissue repair (reducing injuries)
• Neuro-protection (pre-conditioning immunity)
• Enhance neuro-plasticity (development, memory function)

While the negative aspects of neuroinflammation include:

• Cognitive impairment (aging)
• Collateral damage( traumatic injuries)
• Neuronal damage (neurodegenerative diseases)
• Repeated social defeat stress (anxiety, depression)

Simplified Explanation On Neuroinflammation-Video

Have you been feeling anxious or depressed? Have you been forgetful as of late? Are you experiencing inflammatory effects in your brain? Many of these symptoms are signs that you could suffer from neuroinflammation in the brain. The video above explains neuroinflammation and how it is linked to the immune system affecting the body. Since neuroinflammation may cause various health issues such as anxiety, stress, depression, and other well-known symptoms, studies reveal that neuroinflammation is a common feature of neurodegenerative diseases. To that point, the relationship between neuroinflammation and neurodegenerative diseases shows that neuroinflammation has been responsible for the abnormal secretion of proinflammatory cytokines to trigger the signaling pathways to the brain, making it dysfunctional. 

The Link Between Neuroinflammation & Neurodegenerative Diseases

Since the brain is the primary command center for the body, the link between neurodegenerative diseases and neuroinflammation overlap and cause havoc in the body. Studies reveal that inflammatory and neurotoxic mediators are released in the brain, thus viciously triggering neuroinflammation and neurodegeneration in the body. When the body is dealing with neuroinflammation, one of the symptoms that are prominent in the body is chronic oxidative stress. Research studies have revealed that neuroinflammation has been associated with chronic oxidative stress, a vital feature of all neurodegenerative diseases causing genetic structural alterations. To that point, it results in neurodegeneration. Fortunately, there are ways to lower neuroinflammation associated with neurodegenerative diseases. Some of the ways that many people utilize to reduce neuroinflammation include:

• Anti-inflammatory foods (avocados, oily fish, cacao, ginseng, Ginkgo Biloba, etc.)
• Controlling blood sugar
• Exercising
• Managing stress
• Adequate sleep
• Chiropractic care

 All these small changes are remarkable in reducing neuroinflammation and managing neurodegenerative diseases in the body. This will help many individuals dealing with neuroinflammation associated with neurodegenerative diseases and can regain their health and wellness by managing it.

Conclusion

The brain is the primary command center that sends neuron signals to the body to function in everyday movement. The neuron signals travel from the brain to the spinal cord through the numerous nerve roots connected to the muscles, tissues, and ligaments to support the organs and joints. When environmental factors affect the body over time, it risks developing neuroinflammation associated with neurodegenerative diseases. Neuroinflammation is when the inflammatory mediators start to affect the brain, it can make the brain disrupt the neuron signals from traveling to the body and cause issues associated with neurodegeneration. Fortunately, incorporating different ways to reduce neuroinflammation can help manage neurodegenerative diseases and benefit the body.

References

Chen, Wei-Wei, et al. “Role of Neuroinflammation in Neurodegenerative Diseases (Review).” Molecular Medicine Reports, D.A. Spandidos, Apr. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4805095.

DiSabato, Damon J, et al. “Neuroinflammation: The Devil Is in the Details.” Journal of Neurochemistry, U.S. National Library of Medicine, Oct. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC5025335/.

Guzman-Martinez, Leonardo, et al. “Neuroinflammation as a Common Feature of Neurodegenerative Disorders.” Frontiers in Pharmacology, Frontiers Media S.A., 12 Sept. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6751310/.

Kempuraj, D, et al. “Neuroinflammation Induces Neurodegeneration.” Journal of Neurology, Neurosurgery and Spine, U.S. National Library of Medicine, 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC5260818/.

Matsuda, Megumi, et al. “Roles of Inflammation, Neurogenic Inflammation, and Neuroinflammation in Pain.” Journal of Anesthesia, U.S. National Library of Medicine, Feb. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6813778/.

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