Autoimmune Disease & Immunity

The Perioperative use of Nutraceuticals: Probiotics


Nutritional assessment is a critical step that inpatients have to go through before undergoing surgery. Unfortunately, even with the obesity pandemic, most patients fall into the category of malnourished or are at risk of malnutrition. A detrimental nutritional status reflects a slow recovery, increased hospital stay, risk of postsurgical infection, impaired wound healing, and pressure ulceration. Perioperative nutrition uses nutritional support through macro and micronutrients or nutraceuticals 7- 14 days before surgery, during, and after the procedure. In turn, the perioperative use of nutraceuticals improves surgical outcomes and ensures proper healing. Furthermore, combining orthomolecular medicine knowledge and acute care setting procedures can diminish the risk of hyperglycemia and refeeding syndrome. In addition, probiotics have an application in preoperative care with beneficial results in the preparation stage and postsurgical outcome.

Perioperative support: ERAS

Perioperative nutrition is an essential part of the enhanced recovery after surgery (ERAS) initiative. Indeed, ERAS’ priority is to assess nutritional status, correct or improve dietary deficiencies using oral supplementation (enteral nutrition) and bioactive components such as micronutrients, essential fatty acids, and probiotics. Consequently, this nutritional support results in a reduced hospital stay, leading to lower infection risk and wound dehiscence.


There are multiple reports about the gastrointestinal ecosystem and how the balance (symbiosis) between the host and microbiome plays a crucial role in health. Nevertheless, diseases and surgical procedures can disrupt this balance leading to dysbiosis. 

Dysbiosis has a close link with chronic and severe diseases. Also, infections, autoimmune disease, and increased inflammation are part of this dysbiosis ecosystem. Nevertheless, the use of probiotics as preoperative support has a shred of extensive supportive evidence. 


The rationale for the use of probiotics:

  1. Perioperative use of probiotics ensures the reduction of mucosal damage during surgery and prevents medication dysbiosis.
  2. Counteracts the use of antibiotics as prophylaxis: Antibiotics as preparation before surgery associate with “functional” diarrhea to severe conditions like pseudomembranous colitis.
  3. Alleviates microbial disbalance caused by presurgical fasting: Previous studies report a loss of Firmicutes and elevated concentration of Proteobacteria and Bacteroidetes caused by the scarcity of available macronutrients. Additionally, the surgical injury intensifies the presence of postsurgical dysbiosis.
  4. Probiotic supplementation is associated with a restored function of gastrointestinal permeability. Consequently, the protective probiotic effects on intestinal permeability translate to a modulated inflammatory and immune response.
  5. Clinical evidence supports the use of probiotics in reducing infectious complications and reducing anastomosis dehiscence.

Clinical application:

In an experimental study using a probiotic nutraceutical composed of a mixture with Lactobacillus Plantarum LP01 (1 billion living cells), Lactobacillus lactis subspecies cremoris LLC02 (800 million living cells), and Lactobacillus delbrueckii LDD01 (200 million living cells) was put to the test after gastric surgery. 

The symptoms assessed in this study were: abdominal pain, abdominal bloating, flatulence, borborygmi, malaise, weakness, headache, and eructation. Furthermore, the presence of these symptoms was followed for eight weeks. This study reported positive outcomes in all of the symptoms mentioned above.

Orthomolecular medicine’s scope focuses on treating inflammation using nutraceuticals. As a nutritionist, I see the overlapping of conventional medicine in the acute setting and orthomolecular therapy in perioperative nutrition. The benefits associated with probiotics can be applied with positive outcomes in both environments, which enforces the modality of “is not this or that, is this and that.” – Ana Paola Rodríguez Arciniega, MS.


Ali Abdelhamid, Y et al. “Peri-operative nutrition.” Anesthesia vol. 71 Suppl 1 (2016): 9-18. doi:10.1111/anae.13310

Bonavita, Luigi et al. “Postsurgical intestinal dysbiosis: use of an innovative mixture (Lactobacillus Plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, Lactobacillus delbrueckii LDD01).” Acta bio-medica : Atenei Parmensis vol. 90,7-S 18-23. 10 Jul. 2019, doi:10.23750/abm.v90i7-S.8651

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The information herein is not intended to replace a one-on-one relationship with a qualified healthcare professional, licensed physician, and not medical advice. We encourage you to make your own health care decisions based on your research and partnership with a qualified health care professional. Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the musculoskeletal system’s injuries or disorders. Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and issues that relate to and support, directly or indirectly, our clinical scope of practice.* 

Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. In addition, we provide copies of supporting research studies available to regulatory boards and the public upon request. We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900. Read More.

Dr. Alex Jimenez DC, MSACP, CCST, IFMCP*, CIFM*, CTG*


phone: 915-850-0900

Licensed in Texas & New Mexico


Dr. Alex Jimenez

Specialties: Stopping the PAIN! We Specialize in Treating Severe Sciatica, Neck-Back Pain, Whiplash, Headaches, Knee Injuries, Sports Injuries, Dizziness, Poor Sleep, Arthritis. We use advanced proven Integrative Wellness therapies focused on optimal mobility, posture control, health Instruction, functional fitness, Nutrition, and structural conditioning. In addition, we use effective "Patient Focused Diet Plans," Specialized Chiropractic Techniques, Mobility-Agility Training, Cross-Fit Protocols, and the Premier "PUSHasRx Functional Fitness System" to treat patients suffering from various injuries and health problems. Ultimately, I am here to serve my patients and community as a Chiropractor, passionately restoring functional life and facilitating living through increased mobility. So join us and make a living with mobility a way of life. Blessings.

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