Functional Medicine

Is It Really Autoimmunity? | El Paso, TX. | Part II

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Autoimmunity: One of the most common things is to leave the doctor’s office with a diagnosis of an autoimmune disease and no nutritional or lifestyle changing insight. Autoimmune diseases are related to inflammation. Keeping  the inflammation down is the goal with autoimmune attacks. The foods you eat make a huge difference in the frequency and severity of flare-ups. Steady dietary changes can help you reach your optimal self.

Is Autoimmune Disease A Result Of The Collective Perturbations Of The Exposome & Its Impact On The Immunometabolic System?

 

science.sciencemag.org/content/330/6003/460.summary?sid=1ab5a992-4406-499c-b24f-6e7a46c1dc95%5B/caption%5D

The Exposome

Semin Arthritis Rheum. 2018; 47(5): 710‐717.

Exposome Influence On SLE

The Ecology Of The Exposome

Exposome & The Alteration Of “Self”

The Exposome Connections To Autoimmune Diseases Converting Self Into Non‐Self

  • Immunometabolic dysfunctions through diet and lifestyle imbalances
  • Gut Ecology and the Microbiome
  • ViralorBacterialInfections
  • Hormones
  • Drugs
  • Chemicals
  • IonizingRadiation
  • PsychologicalStress

FEBS Lett. 2017 Oct;591(19):3119‐3134.

Cell. 2018 Jan 11;172(1‐2):22‐40.

Cross‐Talk Among The Endocrine, Immune & Metabolic Systems

Multi‐Organ Network Biology

In Autoimmunity, Warburg Metabolism Is Increased Through Increased Activity Of GAPDH

Science. 2018; 360: 377‐78. Dietary Influence?

Blocking Immune Cell Glycolysis & “Starving” Its Function

Science. 2018; 360: 449‐54.

Ketogenic Diet’s Potential Impact On GAPDH Immunometabolic Regulation

Cell. 2018 Jan 11;172(1‐2):162‐175.

Gut Microbes. 2016;7(1):82‐9.

Front Immunol. 2017 Mar 21;8:311.

Origin Of IL‐17 Producing Th17 Cells

What Is The Relationship Of The Gut Microbiome To Autoimmune Disease?

www.cell.com/cell/issue?pii=S0092-8674(17)X0006-8%5B/caption%5D

Science. 2018 Mar 9;359(6380):1097‐98.

Science. 2018 Mar 9;359(6380):1156‐61.

Allergol Int. 2018 Jan 6;67(1):32‐42.

Int J Mol Sci. 2015 Sep 1;16(9):20841‐58.

Science. 2018 Mar 9;359(6380):1151‐56.

High Fiber Influences On Diabetes In Animal Model

80% Of Patients With Autoimmune Disease Are Female

Why?

Estrogen & Autoimmunity

  • The greatest association with autoimmune diseases is the female gender
  • 17‐beta estradiol seems to play a role in activating T cells in autoimmune disease
  • T cells have ER‐alpha receptors that are activated by 17‐beta estradiol resulting in the production of inflammatory cytokines
  • Blocking ER‐alpha receptors may have a beneficial effect on autoimmune activation

Sci Signal. 2018 Apr 17;11(526). piieaap 9415

Eleanor Rogan, PhD IFM Linus Pauling Award Winner

www.JeffreyBland.com

Estrogen & Androgen Metabolism

4‐Hydroxyestrogens & DNA reactivity

www.ncbi.nlm.nih.gov/pubmed/22155198%5B/caption%5D

www.ncbi.nlm.nih.gov/pubmed/21432907%5B/caption%5D

Indole‐3‐Carbinol (I3C) Inhibition Of ER‐Alpha

www.ncbi.nlm.nih.gov/pubmed/27312859%5B/caption%5D

Relationship Of Hepatic Drug Detoxification To Anti‐Nuclear Antibody Development

onlinelibrary.wiley.com/doi/pdf/10.1002/art.1780240805%5B/caption%5D

www.ncbi.nlm.nih.gov/pubmed/24763537%5B/caption%5D

Biomed Res Int. 2015;2015:194031.

www.ncbi.nlm.nih.gov/pmc/articles/PMC4365752/%5B/caption%5D

www.ncbi.nlm.nih.gov/pubmed/18995849%5B/caption%5D

www.ncbi.nlm.nih.gov/pubmed/24530186%5B/caption%5D

Making Friends With Ourselves: Clinical Implications

  • Reduce exposure to agents that activate immunometabolic dysfunction through the exposome
  • – Dietary
  • – Infection
  • – Parasites
  • – Xenobiotics
  • – Hormone
  • – Allergy
  • – Specific medications
  • – Dysbiosis
  • Reduce exposure to DNA damage (radiation, chemicals)
  • Support hepatic detoxification
  • Implement gastrointestinal restoration program
  • Reduce metabolic inflammation and endotoxin
  • Reduce psychological stress factors that activate HPA axis

 

Jeffrey Bland, PhD

Chairman Emeritus & Member, Board of Directors The Institute for Functional Medicine

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Professional Scope of Practice *

The information herein on "Is It Really Autoimmunity? | El Paso, TX. | Part II" is not intended to replace a one-on-one relationship with a qualified health care professional or licensed physician and is not medical advice. We encourage you to make healthcare decisions based on your research and partnership with a qualified healthcare professional.

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Our information scope is limited to Chiropractic, musculoskeletal, physical medicines, wellness, contributing etiological viscerosomatic disturbances within clinical presentations, associated somatovisceral reflex clinical dynamics, subluxation complexes, sensitive health issues, and/or functional medicine articles, topics, and discussions.

We provide and present clinical collaboration with specialists from various disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system.

Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and directly or indirectly support our clinical scope of practice.*

Our office has reasonably attempted to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.

We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez, DC, or contact us at 915-850-0900.

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Dr. Alex Jimenez DC, MSACP, RN*, CCST, IFMCP*, CIFM*, ATN*

email: coach@elpasofunctionalmedicine.com

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