Nerve Injury

Brain Inflammation and Fatigue in Functional Neurology


How often do you become fatigued when driving compared to in the past? Or how often do you become fatigued when reading compared to in the past? And, how often do you feel you are not getting enough sleep or rest? If you experience any of these problems often, you may be experiencing brain inflammation and fatigue due to a variety of health issues.  


Chronic fatigue syndrome (CFS) and other similar health issues, such as Gulf War illness (GWI), share many common symptoms, several of which can include muscle pain and discomfort, fatigue, cognitive impairment, disrupted sleep, sore throat, headaches, and general malaise, typically after participating in any type of physical activity or exercise.  


CFS has frequently been referred to as a mental health issue. In 2015, a National Academy of Medicine-led comprehensive overview of scientific literature and patients’ accounts cautioned that many healthcare professionals are doubtful about the seriousness of CFS, commonly mistaking it for a mental health issue or believe it a figment of the patient’s imagination.”  


Moreover, the research study also supports that healthcare professionals should admit CFS as a health issue which needs diagnosis and treatment. The review also discussed what at the time was ultimately considered unknown causes of CFS.  


Although important progress was developed in the manner that chronic fatigue syndrome (CFS) is diagnosed and perceived in the medical community, there’s currently no known treatment for the health issue and its causes still remain unknown.  


New research studies, however, offer new hope for fast and precise diagnosis of the health issue, as changes in brain chemistry associated with inflammation and neurological diseases have been found. Between 836,000 and 2.5 million people in the United States suffer from CFS. The findings may also help people with CFS receive successful treatment.  


Furthermore, one research study, which was directed by researchers at Georgetown University Medical Center in Washington, D.C., identified changes in brain chemistry that also exist in other similar health issues, such as GWI, a health issue which is ultimately believed to have affected approximately 175,000 war veterans returning from the Gulf War.  


Analyzing the Brain in Chronic Fatigue Syndrome


Dr. James N. Baraniuk, a professor of medicine at Georgetown University School of Medicine, led the new research study, along with the findings which have been published in the journal Scientific Reports. Dr. Baraniuk and his group of researchers analyzed the cerebrospinal fluid of people with CFS and other health issues, such as GWI, in addition to healthy controls.  


The group pulled the fluid with a lumbar puncture, before and after the individuals participated in a session of physical activity or exercise. The group additionally analyzed the brains of the individuals utilizing functional MRI (fMRI).  


The physical activity or exercise sessions lasted for 25 minutes and consisted of riding a stationary bicycle. The bike immunity increased as predicted by their own era, so the participants reached 85 percent of their maximum heart rate.  


Before participating in any physical activities or exercises, amounts of microRNA (miRNA), which are responsible for regulating protein generation, were exactly the exact same in all the individuals participating in the research study. However, 24 hours following the physical activities or exercises, this changed for the three distinct groups of participants.  


Every class had a different pattern of modification. The researchers stated, “CFS had 12 diminished miRNAs following physical activity or exercise.” Despite symptom overlap of CFS, GWI and other health issues in their differential diagnosis, miRNA patterns in cerebrospinal fluid signaled different mechanisms for post-exertional malaise in CFS and GWI.  


Additionally, the analysis also discovered miRNA changes in just two subtypes of GWI. Tachycardia that lasted for two to three days after the workout was developed by 1 subgroup. FMRI investigations revealed that these individuals had smaller brainstems in brain regions responsible for controlling the heartbeat. FMRI scans showed decreased brain activity.  


Another GWI group, however, introduced neither modifications to heart rate nor brainstem atrophy, but its own associates appeared to need extra brain regions so as to do a memory task. Surprisingly, Dr. Baraniuk discussed that the miRNA changes found in such states were different from those observed in depression, fibromyalgia, and Alzheimer’s disease, among others.  


“We certainly see three distinct patterns in the brain’s production of those molecules at the CFS group and both GWI phenotypes. This information will probably be well-received by individuals that suffer from such ailments that are misdiagnosed and rather may be medicated for depression or other psychological disorders,” stated Dr. James N. Baraniuk. 


New research studies have demonstrated that changes in brain chemistry associated with inflammation may cause fatigue. Health issues like chronic fatigue syndrome and Gulf War illness are believed to be caused by neuroinflammation and other molecule changes in the brain. In the following article, inflammation and fatigue, can be caused due to a variety of causes, although the causes still remain mostly unknown. Although fatigue may be a frustrating symptom, relief is possible with proper treatment. – Dr. Alex Jimenez D.C., C.C.S.T. Insight



Neurotransmitter Assessment Form


The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. Symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue.  



In honor of Governor Abbott’s proclamation, October is Chiropractic Health Month. Learn more about the proposal.  


Has it become harder for you to learn new things? Or is your temperament generally getting worse? How often do you get fatigued after meals? If you’ve experienced any of these situations, you may have brain inflammation. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .  


Curated by Dr. Alex Jimenez  



Additional Topic Discussion: Chronic Pain


Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.




Neural Zoomer Plus for Neurological Disease


Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual’s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention.  


Formulas for Methylation Support


XYMOGEN’s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.


Proudly, Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.


Please call our office in order for us to assign a doctor consultation for immediate access.


If you are a patient of Injury Medical & Chiropractic Clinic, you may inquire about XYMOGEN by calling 915-850-0900.


For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download  


* All of the above XYMOGEN policies remain strictly in force.




Dr. Alex Jimenez

Specialties: Stopping the PAIN! We Specialize in Treating Severe Sciatica, Neck-Back Pain, Whiplash, Headaches, Knee Injuries, Sports Injuries, Dizziness, Poor Sleep, Arthritis. We use advanced proven Integrative Wellness therapies focused on optimal mobility, posture control, health Instruction, functional fitness, Nutrition, and structural conditioning. In addition, we use effective "Patient Focused Diet Plans," Specialized Chiropractic Techniques, Mobility-Agility Training, Cross-Fit Protocols, and the Premier "PUSHasRx Functional Fitness System" to treat patients suffering from various injuries and health problems. Ultimately, I am here to serve my patients and community as a Chiropractor, passionately restoring functional life and facilitating living through increased mobility. So join us and make a living with mobility a way of life. Blessings. Dr. Alex Jimenez DC, MSACP, CCST, CIFM, IFMCP, ATN

Published by

Recent Posts

Medial Tibial Stress Syndrome: Shin Splints

When stress is placed on the shins with physical activity from walking, running, or exercise,… Read More

January 18, 2022

Taking A Look At Stress & The Immune Brain Connection | Part 1

Introduction Throughout the entire body system, everything is connected. From the gut to the brain,… Read More

January 18, 2022

Physical Wellness, Diet, and Chiropractic

A healthy diet and proper nutrition are essential for the body's overall health and physical… Read More

January 17, 2022

Thoracic Back Pain

The thoracic spine, also known as the upper or middle back, is designed for stability… Read More

January 14, 2022

Looking Into A Metabolic Approach on Thyroid Disorders | Part 3

Introduction The thyroid is a butterfly-shaped organ that is located at the base of the… Read More

January 14, 2022

Nerve Injury

A nerve injury is often caused by a sudden traumatic event, like a slip and… Read More

January 13, 2022