Dr. Alex Jimenez, El Paso's Chiropractor
I hope you have enjoyed our blog posts on various health, nutritional and injury related topics. Please don't hesitate in calling us or myself if you have questions when the need to seek care arises. Call the office or myself. Office 915-850-0900 - Cell 915-540-8444 Great Regards. Dr. J

Ellagitannins: Gut-Derived Metabolites and their Thermogenic Effects

Gut microbiota has a wide variety of metabolic activities. I would like to rephrase that, more than activities, they are responsibilities. Nowadays, we know that the gut microbiota metabolizes what we used to believe to be “undigestible,” creating microflora-derived metabolites. Consequently, these metabolites promote the growth of beneficial bacteria leading to healthier wellbeing. Nevertheless, the central mediator to this phenomenon relies on the host’s dietary intake of “undigestible” fibers, phytonutrients, and other bioactive components found in different foods. Recently, the identification of beneficial compounds has shed some light on ellagitannins (ET). Ellagitannins (ET) promote the formation of gut-derived metabolites associated with lower cardiovascular risk, body composition improvement, thermogenesis, and aging. 

Ellagitannins 

Ellagitannins (ET) are found in pomegranate juice, walnuts, red berries, and strawberries. If we see these foods from an evolution point of view, humans have consumed these fruits since the hunter-gatherer days. 

In the digestive tract, ET is rapidly metabolized to ellagic acid (EA). Nevertheless, the gut’s microbiota is responsible for the remaining metabolic processes in which EA is converted to urolithin. Furthermore, urolithin has five different isoforms:

  • urolithin A (UA)
  • urolithin B (UB)
  • urolithin C (UC)
  • urolithin D (UD)
  • iso-urolithin A (iso-UA)

High levels of ET can be detected in serum after 40 minutes of pomegranate juice ingestion but undetectable after just five hours of its consumption. On the other hand, urolithins can be seen in urine after 48h of pomegranate juice consumption. Urolithin has higher anti-inflammatory and antioxidant properties than those found in ET However, studies show that these levels of urolithin can be detectable in some patients, but not in all of them. Consequently, this is highly dependent on the variety and interaction between different bacterial strains and the metabolites that they produce. 

ET and obesity.

Recent studies have reported the effects of obesity-associated bacteria and the production of urolithin isoforms. Indeed, a study in obese individuals converted pomegranate and walnut-derives ET into UA, iso-UA, and UB, and other individuals only produced UA. Conversely, those individuals who made high UA levels had a lower risk of developing cardiometabolic disease.

Aging is also a crucial predictor of lower species-specific formation of urolithins from ET. This phenomenon is highly coincidental with the interindividual and age-related differences in gut microbiome composition. 

Not all urolithins are the same…

Up to date, we know that the UA isomer is associated with anti-cancer effects, is anti-inflammatory, and also anti-aging properties. Indeed, UA’s anti-cancer effects are related to its preventive action by reducing cell proliferation and metastasis in prostate and colorectal cancer cells.

Also, UA production by the gut microbiota has coincided with the inhibition of lipopolysaccharide-induced inflammation in macrophages. This last statement was tested in murine models.

UA mitochondrial function, longevity, and body composition.

UA has recently gained an FDA certificate of approval thanks to the results of a fascinating clinical trial. Researchers tested UA’s efficacy on skeletal muscle function and safe use of this bioactive component in their clinical trial. Furthermore, 36 patients were intervened with a single dose of 1000mg of UA for 28 days and then followed by multiple dosing for another 28 days. After this trial period, the patients were tested for mitochondrial gene expression and plasma acylcarnitine. Consequently, the researchers reported an improvement of mitochondrial function on skeletal muscle without any side effects.

UA, UC, and UD: lipid metabolism

Another outstanding research paper reported reduced triglyceride accumulation and fatty acid oxidation associated with higher circulating UA, UC, and UD levels. In fact, UA inhibits triglyceride accumulation in adipocytes, which associates with a reduced expression of adipogenesis-related genes.

UA supplementation’s foundation relies on its anti-inflammatory effects that enhance insulin sensitivity and the thermogenesis effect it stimulates. UA enhances adipose tissue production of T3 from a genetic point of view, leading to an upregulation of thermogenic genes: PCG1a and UCP-1. Consequently, the upregulation of these genes increases energy expenditure and improves body composition by lowering body fat mass.

Finally, the benefits of gut-derived metabolite UA are coincidental with an improvement in body composition. However, studies show that the main result of UA supplementation is a reduction in body fat mass. Ultimately, this results in lower levels of pro-inflammatory markers and better mitochondrial function. Also, UA promotes mitochondrial metabolism of dietary fat, improving energy utilization and skeletal muscle function. All of these mechanisms of action position ET and UA as potent mediators of overall health, reflecting in better body composition, ultimately ensuring longevity and mobility.

Human UA studies are scarce. However, the information reported by mouse models is promising. Nevertheless, UA’s benefits and production depend on a healthy and varied microbiota and the ingestion of foods like strawberries, pomegranate, red berries, and walnuts. Furthermore, the production of this metabolite provides a wide array of benefits that mainly focus on the production of energy by dietary fat in the mitochondria and less synthesis of adipocytes. In turn, this reflects improved muscular function, which enhances mobility and overall higher quality of living. – Ana Paola Rodríguez Arciniega, MS

References:

Xia, Bo et al. “Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice.” PLoS biology vol. 18,3 e3000688. 27 Mar. 2020, doi:10.1371/journal.bio.3000688

Additional Online Links & Resources (Available 24/7)

 

Online Appointments or Consultations: https://bit.ly/Book-Online-Appointment

 

Online Physical Injury / Accident Intake Form: https://bit.ly/Fill-Out-Your-Online-History 

 

Online Functional Medicine Assessment: https://bit.ly/functionmed

Again, I Welcome You 👊🏻.

Our Purpose & Passions: I am a Doctor of Chiropractic specializing in progressive, cutting-edge therapies and functional rehabilitation procedures focused on clinical physiology, total health, practical strength training, and complete conditioning. We focus on restoring normal body functions after neck, back, spinal and soft tissue injuries.

We use Specialized Chiropractic Protocols, Wellness Programs, Functional & Integrative Nutrition, Agility & Mobility Fitness Training, and Rehabilitation Systems for all ages.

As an extension to effective rehabilitation, we too offer our patients, disabled veterans, athletes, young and elder a diverse portfolio of strength equipment, high-performance exercises, and advanced agility treatment options. We have teamed up with the cities premier doctors, therapists,s, and trainers to provide high-level competitive athletes the possibilities to push themselves to their highest abilities within our facilities.

We’ve been blessed to use our methods with thousands of El Pasoans over the last three decades allowing us to restore our patients’ health and fitness while implementing researched non-surgical methods and functional wellness programs.

Our programs are natural and use the body’s ability to achieve specific measured goals, rather than introducing harmful chemicals, controversial hormone replacement, unwanted surgeries, or addictive drugs. We want you to live a functional life that is fulfilled with more energy, a positive attitude, better sleep, and less pain. Our goal is to ultimately empower our patients to maintain the healthiest way of living.

With a bit of work, we can achieve optimal health together, no matter the age or disability.

Join us in improving your health for you and your family.

It’s all about: LIVING, LOVING & MATTERING! 🍎

Welcome & God Bless

EL PASO LOCATIONS

Central:
6440 Gateway East, Ste B
Phone: 915-850-0900

East Side:
11860 Vista Del Sol, Ste 128
Phone: 915-412-6677

Clinic Location 1

Address: 11860 Vista Del Sol Dr Suite 128
El Paso, TX 79936
Phone
: (915) 412-6677
EmailSend Email
Webwww.DrAlexJimenez.com

Clinic Location 2

Address: 6440 Gateway East, Building B
El Paso, TX 79905
Phone: (915) 850-0900
EmailSend Email
Webwww.ElPasoBackClinic.com

Clinic Location 3

Address: 1700 N Zaragoza Rd # 117
El Paso, TX 79936
Phone: (915) 850-0900
EmailSend Email
Webwww.ChiropracticScientist.com

Push As Rx Crossfit & Rehab

Address: 6440 Gateway East, Building B
El Paso, TX 79905
Phone
: (915) 412-6677
EmailSend Email
Webwww.PushAsRx.com

Push 24/7

Address: 1700 E Cliff Dr
El Paso, TX 79902
Phone
: (915) 412-6677
EmailSend Email
Webwww.PushAsRx.com

🔴 Rated Top El Paso Doctor & Specialist by ✔️ RateMD* | Years 2014,2015,2016,2017,2018,2019

Call (915) 850-0900 Today!

EVENTS REGISTRATION: Live Events & Webinars* ❗️

(Come Join Us & Register Today)

Additional Online Links & Resources (Available 24/7)

  1. Online Appointments or Consultations:  https://bit.ly/Book-Online-Appointment
  2. Online Physical Injury / Accident Intake Form: https://bit.ly/Fill-Out-Your-Online-History
  3. Online Functional Medicine Assessment: https://bit.ly/functionmed

Disclaimer

The information herein is not intended to replace a one-on-one relationship with a qualified health care professional, licensed physician, and is not medical advice. We encourage you to make your own health care decisions based on your research and partnership with a qualified health care professional. Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the musculoskeletal system’s injuries or disorders. Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and support, directly or indirectly, our clinical scope of practice.* Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request. We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 Read More…

Dr. Alex Jimenez DC, MSACP, CCST, IFMCP*, CIFM*, CTG* 

email: coach@elpasofunctionalmedicine.com
phone: 915-850-0900
Licensed in Texas & New Mexico